Beta-blockers or placebo for primary prophylaxis of oesophageal varices (BOPPP study)

BOPPP is a multi-site NIHR HTA funded randomised controlled trial that examines the use of non-selective beta-blockers in patients with small oesophageal varices. BOPPP has incorporated a Qualitative Research component into the Protocol to understand the barriers and enablers of trial recruitment at two levels (i) patient level, (ii) research site level.

Patients who are approached for trial participation will also be invited to take part in an interview to understand barriers and enablers of trial recruitment. Patients who have consented into the Trial and those who have declined will be interviewed. In addition, research nurses, endoscopists, pharmacists and general practitioners will be interviewed to provide their perspectives on recruitment, retention and Trial intervention implementation.